apComplex (version 2.38.0)

Krogan complexes: Krogan data complex estimates

Description

Affiliation matrices with rows corresponding to proteins and columns corresponding to complexes.

Usage

data(MBMEcKrogan)

Source

Scholtens D and Gentleman R. Making sense of high-throughput protein-protein interaction data. Statistical Applications in Genetics and Molecular Biology 3, Article 39 (2004). Scholtens D, Vidal M, and Gentleman R. Local modeling of global interactome networks. Bioinformatics 21, 3548-3557 (2005).

Details

These are the results from an analysis of the AP-MS data (Krogan et al., 2004). These estimates were constructed using findComplexes with a sensitivity parameter of .75, specificity of .99, and Beta=-0.2 for externally derived similarity measure based on Gene Ontology cellular component annotation (see Scholtens and Gentleman (2004)).

MBMEcHMSPCI contains 82 multi-bait-multi-edge complex estimates.

References

High-Definition Macromolecular Composition of Yeast RNA-Processing Complexes; Molecular Cell, Vol 13, 225-239, 30 January 2004

Examples

data(MBMEcKrogan)
MBMEcKrogan[1:4,1:4]